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Fb2 In Vitro Toxicity Indicators, Volume 1B (Methods in Toxicology) ePub

by Charles A. Tyson,John M. Frazier,Hanspeter Witschi

Category: Medicine and Health Sciences
Subcategory: Other
Author: Charles A. Tyson,John M. Frazier,Hanspeter Witschi
ISBN: 0124612032
ISBN13: 978-0124612037
Language: English
Publisher: Academic Press; 1 edition (May 9, 1994)
Pages: 497
Fb2 eBook: 1447 kb
ePub eBook: 1350 kb
Digital formats: lrf mbr azw lit

Methods in Toxicology. In Vitro Toxicity Indicators.

Methods in Toxicology. eBook ISBN: 9780080924403. Imprint: Academic Press. Published Date: 22nd October 2013. Membrane Integrity and Function: Enzyme Leakage as an Indicator of Cytotoxicity in Cultured Cells, . Welder and D. Acosta. Cellular K+, V. Kefalas and . Morphological and Biochemical Investigations on Plasma Membrane Blebbing During Cell Injury, G. Bellomo, F. Mirabelli, M. Vairetti, F. Iosi, and W. Malorni.

Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. 1. Materials and Design. The Art and Science of Material Selection in Product Design. Michael F. Ashby and Kara Johnson (Auth.

In Vitro Toxicity Indicators book. About the Series: In the tradition of Methods in Enzymology and Methods in Neurosciences, Academic Press is pleased to announce a new serial: Methods in Toxicology.

In book: In Vitro Toxicology. Cite this publication. Background: There is a need to develop in vitro models to test drugs and chemicals that induce toxicity in the male reproductive system. We have evaluated an in vitro mouse testis organ culture model capable of producing viable, sperm as a possible toxicity test model. Although this in vitro model was limited to round spermatid differentiation, histopathology observations could still be performed.

In Vitro Toxicity Indicators (Methods in Toxicology, Volume 1, Part B). Close. 1 2 3 4 5. Want to Read.

Volume 1 examines ''in vitro'' biological systems. Historically, these methods have made significant contributions to our understanding of mechanisms of action toxins and xenobiotic metabolism and, in this context, have provided an indispensable resource for investigative toxicology. More recently, the value of ''in vitro'' systems as toxicity tests for chemical safety and hazard evaluation has been recognized and explored

San Diego, California, USA: Academic Press.

San Diego, California, USA: Academic Press. Published: 1 November 1993.

Charles A. Tyson, John M. Frazier. The book discusses the in vitro models of neural and neuromuscular systems; ocular system; respiratory system; cardiovascular system; and gastrointestinal system. Elsevier, 20 avr. 2016 - 592 pages. Methods in Toxicology, Volume 1: In Vitro Biological Systems, Part A provides basic techniques employed by widely recognized scientists to prepare and maintain the biological components of in vitro model systems. The book discusses the in vitro models of neural and neuromuscular systems; ocular system; respiratory system; cardiovascular system; and gastrointestinal system

Methods in Toxicology Pt. B Vol. 1 : In Vitro Toxicity Indicators. In the tradition of METHODS IN TOXICOLOGY AND METHODS IN NEUROSCIENAES, Academic Press is pleased to announce a new serial: METHODS IN TOXICOLOGY.

Methods in Toxicology Pt.

About the Series:In the tradition of Methods in Enzymology and Methods in Neurosciences, Academic Press is pleased to announce a new serial: Methods in Toxicology. There is a pressing need among researchers involved in toxicologic investigation for a series of publications that organizes and presents information on the latest experimental methodologies. To address the needs of researchers in toxicology, toxicologic pathology, pharmacology, and clinical biochemistry, this new serial provides comprehensive descriptions of state-of-the-art methods for evaluating drug and chemical toxicity. Thematic volumes focus on mechanistic approaches to the study of toxicity both in vitro and in vivo, taking advantage of the recent advances in the biological and chemical sciences that allow closer scrutiny of the mechanisms by which agents cause damage. Each volume begins with an introductory chapter that offers a broad guide to the application of methods addressed in that volume. Subsequent chapters contain detailed descriptions of research protocols, accessible both to experts and those new to toxicologic investigation. Included in each chapter are clearly defined procedures, discussions of limitations of the method, comparative considerations (species, sex, strain), interpretations of results, and explanations of how the methods may serve as alternatives to in vivo testing. Each volume of Methods in Toxicology is available in case binding for the library and Wire-O-binding for the laboratory. About the Book:Concurrent with the development of biological systems for in vitro toxicologic investigations (Volume 1A-In Vitro Biological Systems), techniques have evolved to detect and evaluate the diverse effects produced when toxicants interact with these systems. This volume describes methods for detecting and quantifying pertubations in various cellular parameters related to cell dysfunction and death (including apoptosis) associated with adverse toxicant action. Each endpoint measurement probes one aspect of the response of the biological system to a toxicant. When several techniques are used in combination, it is possible to derive a more complete understanding of the mechanism of toxicity at the cellular, tissue, or organ level. The methods collected here are organized by major categories of toxic effects, such as membrane damage, disruption of energy metabolism, and lipid peroxidation, commonly monitored by toxicologists during a comprehensive toxicity study. Specialized techniques of interest and value in mechanistic investigations are included. As with the first volume, the goal is not to obtain an exhaustive collection of methods, but rather to assemble in a single central reference a set of valuable techniques that are used for toxicologic investigations, along with cautionary remarks on their use and limitations.
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