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Fb2 Drug Targeting: Strategies, Principles, and Applications (Methods in Molecular Medicine) ePub

by G. E. Francis

Category: Medicine and Health Sciences
Subcategory: Other
Author: G. E. Francis
ISBN: 089603531X
ISBN13: 978-0896035317
Language: English
Publisher: Humana Press; 2000 edition (April 21, 2000)
Pages: 318
Fb2 eBook: 1733 kb
ePub eBook: 1872 kb
Digital formats: lit rtf azw mbr

Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals.

In Drug Targeting: Strategies, Methods, and Protocls, Gillian E. Francis and Cristina Delgado have assembled an outstanding collection of leading-edge protocols for drug targeting studies

In Drug Targeting: Strategies, Methods, and Protocls, Gillian E. Francis and Cristina Delgado have assembled an outstanding collection of leading-edge protocols for drug targeting studies.

In Drug Targeting: Strategies, Principles, and Applications we have tried to compile a state-of-the-art volume on current targeting approaches

In Drug Targeting: Strategies, Principles, and Applications we have tried to compile a state-of-the-art volume on current targeting approaches. The first section focuses on certain key strategies applied to date, and how to build the antibody- ligand constructs. This is followed by a section on theoretical considerations for t- geting, focusing on approaches relevant to solid tumors. The last section deals with some experimental and clinical applications of targeted drug delivery systems.

Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce todays emerging rich array of novel diagnostic agents and promising.

Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce todays emerging rich array of novel diagnostic agents and promising biopharmaceuticals

Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within . The three-dimensional structure of the molecular target is employed in molecular modeling studies.

Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. This approach also estimates the ligand-receptor binding free energy by evaluating critical phenomena involved in the intermolecular recognition process. Given that bioactive small-molecules are discovered, the structure of a ligand-receptor complex can be obtained.

methods, including molecular modeling, as powerful tools for the study of. .Phenotypic and targetbased approaches are useful methods in drug discovery.

methods, including molecular modeling, as powerful tools for the study of structure-activity. In addition to pharmacodynamics data (. Understanding the principles by which small-molecule ligands recognize and interact with. The phenotypic approach is an experimental approach for evaluating the phenotypic response.

Fibonacci Applications and Strategies for Traders: Unveiling the Secret of the Logarithmic Spiral. Drug Targeting: Strategies, Principles, and Applications.

Drug-Like Properties: Concepts, Structure Design and Methods from .

Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. High throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, translational medicine, and many other scientific methods that have become critical to the successful development of marketable therapeutics are described.

Advances in understanding the molecular mechanisms of disease together with the advent of recombinant DNA and other technologies have opened opportunities for a vast array of novel therapeutic biopharmaceuticals and diagnostic agents. However, even natural biomolecules present a myriad of problems that limit their potential as pharmaceutical agents.

Advances in understanding the molecular mechanisms of disease together with the advent of recombinant DNA and other technologies have opened opportunities for a vast array of novel therapeutic biopharmaceuticals and diagnostic agents. However, even natural biomolecules present a myriad of problems that limit their potential as pharmaceutical agents. Rapid degra- tion and elimination, immunological reactions, and toxicity are often asso- ated with new biopharmaceuticals, much as with conventional agents. Targeted delivery systems have the potential to increase the efficacy of existing diagnostic and therapeutic agents and also create an opportunity for the use of new pharmaceuticals, substances that themselves can be harmful to normal tissues. Both passive and active targeting have been exploited. Most active targ- ing strategies have focused on antibody conjugates since preparation of highly specific monoclonal antibodies is well established. However, a new wave of c- jugates exploiting other ligands is underway. Access to the target tissue remains an obstacle and is an area where passive targeting can be useful. In Drug Targeting: Strategies, Principles, and Applications we have tried to compile a state-of-the-art volume on current targeting approaches. The first section focuses on certain key strategies applied to date, and how to build the antibody– ligand constructs. This is followed by a section on theoretical considerations for t- geting, focusing on approaches relevant to solid tumors. The last section deals with some experimental and clinical applications of targeted drug delivery systems.
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