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Fb2 Approaches to Elucidate Mechanisms in Teratogenesis ePub

by Frank Welsch

Category: Medicine
Subcategory: Medical Books
Author: Frank Welsch
ISBN: 0891165843
ISBN13: 978-0891165842
Language: English
Publisher: CRC Press; 1 edition (July 1, 1987)
Pages: 285
Fb2 eBook: 1984 kb
ePub eBook: 1115 kb
Digital formats: azw docx mobi lrf

Valproic acid teratogenesis: demonstration that the biochemical mechanism differs from that of valproate . Studies on the mechanisms of dose-response relationships. In Approaches to Elucidate the Mechanisms in Teratogenesis (ed. F. Welsch), 59–81

Valproic acid teratogenesis: demonstration that the biochemical mechanism differs from that of valproate hepatoxicity. Biochemical Society Transactions 13, 75–77. Welsch), 59–81. Washington, DC, USA: Hemisphere.

PDF There are multiple mechanisms by which alcohol can damage the developing brain, but the . Diffusion tensor imaging (DTI) has revolutionized our understanding of the neural underpinnings of alcohol teratogenesis

PDF There are multiple mechanisms by which alcohol can damage the developing brain, but the type of damage induced will depend on the amount an. .Diffusion tensor imaging (DTI) has revolutionized our understanding of the neural underpinnings of alcohol teratogenesis. Using Prisma guidelines, we identified 23 DTI studies conducted on individuals with prenatal alcohol exposure (PAE).

We have studied four organic acids of similar structure to further understand the basis of their developmental toxicity. Valproic acid (2-propyl pentanoic acid), ethylhexanoic acid, and octanoic acid are isomeric C8 organic acids but their teratologic potency varied widely. Valproic acid induced a moderate to severe teratologic outcome after a single oral administration of . 5 mmoles/kg on day 12 of rat pregnancy. Twice as much ethylhexanoic acid (1. mmoles/kg) induced a less severe response. Octanoic acid was nonteratogenic even at the very high dose of 1. 5 mmoles/kg.

An alternative mechanism for teratogenesis due to thalidomide was proposed by Arlen and Wells (1996), Parman et a.

An alternative mechanism for teratogenesis due to thalidomide was proposed by Arlen and Wells (1996), Parman et al. (1999), and Wells et al. (2010a,b) where its metabolism may be catalyzed by embryonic prostaglandin H synthase (also known as cyclooxygenase) to reactive free radical intermediates. Although the story is not completely elucidated the current hypothesis involves blocking angiogenesis of endothelial cells lining the blood vessels leading to growth factor signaling, cell death and mesenchymal loss (Vergesson, 2009).

Signaling mechanisms in pituitary morphogenesis and cell fate determination.

Pp. 17-31 in Approaches to Elucidate Mechanisms in Teratogenesis, F. Welsch, ed. Washington, DC: Hemisphere Pub. Brown, . J. Kao, and S. Fabro. Signaling mechanisms in pituitary morphogenesis and cell fate determination.

The underlying mechanisms that lead to dramatic differences between closely related pathogens are not always readily apparent. In this study, a temporal multi-omic analysis of YP and YPT at physiologically relevant temperatures was performed to gain insights into how an acute and highly lethal bacterial pathogen, YP, differs from its less virulent progenitor, YPT. This analysis revealed higher gene and protein expression levels of conserved major virulence factors in YP relative to YPT, including the Yop virulon and the pH6 antigen.

relationships between mechanisms that are conserved/divergent in vitro and in vivo gene- compound, and compound-compound synergy Our center will develop algorithms to help elucidate ho.

2  AIM 1: Developing new graph-theoretical methods for the analysis of LINCS profiles to establish relationships between mechanisms that are conserved/divergent in vitro and in vivo

Prior work has failed to identify the underlying immunological mechanisms, which would pave a path towards an HIV vaccine.

Prior work has failed to identify the underlying immunological mechanisms, which would pave a path towards an HIV vaccine. One key limitation of current approaches is a disproportionate emphasis on antibody (Ab), rather than systematic analysis of the full repertoire of Ab effector functions. We employ a systems serology approach to address this. We analyze a cohort of 78 human subjects comprising four distinct patient groups exhibiting varying degrees of HIV control, and one control group.

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